Friday November 21, 2008


Q: Is there a difference in metabolism between Cleviprex (clevidipine butyrate) and other dihydropyridine Calcium Channel blocker?

IV Clevidipine butyrate(cleviprex) is rapidly metabolized by hydrolysis of the ester linkage, primarily by esterases in the blood and extravascular tissues. In contrast, earlier generation of dihydropyridine calcium channel blockers, such as nicardipine or nifedipine are metabolized by liver or kidney. It can be titrated depending on the response of the individual patient to achieve the desired blood pressure reduction.

The elimination of clevidipine butyrate is unlikely to be affected by hepatic or renal dysfunction. Therefore, no dosing adjustment is necessary in patients with renal or hepatic dysfunction. Unlike nicardipine, the clevidipine does not accumulate in the body, and its clearance is therefore independent of body weight.