Tuesday November 18, 2008

Characteristics of IV Antihypertensive agents

The following medicines are described for five effects

1. Therapy class
2. Onset of Action
3. Duration of action
4. Preload
5. Afterload

Nicardipine is Dihydropyridine Calcium Channel Blocker with onset in 5-10 minute and duration of action 2-4 hours. It has No effect on Preload but decrease afterload.

Clevipidine Nicardipine is Dihydropyridine Calcium Channel Blocker with onset in 1 minute and duration of action 10 minutes. It has No effect on Preload but decrease afterload.

Esmolol is Dihydropyridine Beta Blocker with onset in 6-10 minutes and dutation of action 20 minutes. It has No effect on Preload or afterload.

Fenoldopam is Dihydropyridine Dopamine-D1 like receptor agonist with onset in 10-15 minutes and duration of action 10-15 minutes. It has No effect on Preload but decrease afterload.

Hydralazine is Arterial Vasodilator with onset in 10 minutes and duration of action 2-6 hours. It has No effect on Preload but decrease afterload.

Labetolol is Selective alpha and non-selective beta adrenergic receptor blocker with onset in 5-10 minutes and duration of action 2-6 hours. It has No effect on Preload but decrease afterload.

Nitroglycerine is Nitrovasodilator with onset in 2-5 minutes and duration of action 10-20 minutes. It has No effect on Preload and minimal effect on afterload.

Sodium nitroprusside is Nitrovasodilator with onset in few seconds and duration of action 1-2 minutes. It has decrease Preload and afterload.